Product: Anadrol 50
Active substance: Oxymetholone Packaging: 50mg x 100 tablets Volume: 100 tabs (total 500 mg)
Price: $49.50 (€43.86)
50-150 mg/day (men)
Side effects: Anadrol can cause acne problems, it is Very liver toxic,
it retents water, increases blood pressire.
It Decreases HPTA function in extreme measures. Since it's
a DHT derivate it won't convert DHT.
Active Life: Less than 16 hours
Drug Class: Highly Anabolic/Androgenic Steroid.
Anadrol 50 is the U.S. brand name for oxymetholone, a very potent oral androgen. This compound was first made available in
1960, by the international drug firm Syntex. Since oxymetholone is quite reliable in its ability to increase red blood cell production (and effect
admittedly characteristic of nearly all anabolic/androgenic steroids), it showed particular promise in treating cases of severe anemia. For this
purpose it turned out to be well suited, and was popular for quite some time. But recent years have brought fourth a number of new treatments,
most notably the non-steroidal hormone Epogen (erythropoietin). This item is shown to have a much more direct effect on the red blood cell count,
without the side effects of a strong androgen. Financial disinterest finally prompted Syntex to halt production of the U.S. Anadrol 50 in 1993,
which was around the same time they decided to drop this item in a number of foreign countries. Plenastril from Switzerland and Austria was dropped;
following soon was Oxitosona from Spain. Many Athletes feared Anadrol 50 might be on the way out for good. But new HIV/AIDS studies have
shown a new light on oxymetholone. These studies are finding (big surprise) exceptional anti-wasting properties to the compound and believe it can
be used safely in many such cases. Interest has been peaked, and as of
1998 Anadrol 50 is again being sold in the United States. This
time we see the same Anadrol 50 brand name, but the manufacturer
is the drug firm Unimed. Syntex continues to market & license this
drug in a number of countries however (under a few different brand names).
It is important to note however, that this drug does not directly convert
to estrogen in the body. Oxymetholone is a derivative of dihydrotestosterone,
which gives it a structure that cannot be aromatized. As such, many have
speculated as to what makes this hormone so troublesome in terms of estrogenic
side effects. Some have suggested that it has progestational activity,
similar to nandrolone, and is not actually estrogenic at all. Since the
obvious side effects of both estrogens and progestins are very similar,
this explanation might be a plausible one. However we do find medical
studies looking at this possibility. One such tested the progestational
activity of various steroids including nandrolone, norethandrolone, methandrostenolone,
and oxymetholone 3. It reported no significant progestational effect inherent
in oxymetholone or methandrostenolone, slight activity with testosterone
and strong progestational effect inherent in nandrolone and norethandrolone.
With such findings it starts to seem much more likely that oxymetholone
can intrinsically activate the estrogen receptor itself, similar to but
more profoundly than the estrogenic androgen methAndriol. In speaking
with chemist Patrick Arnold about my thoughts on this, I was afforded
very believable support for my suspected explanation. According to Pat:
"I share your thoughts on this. Anadrol has an acidic hydrogen
in the A-ring at a vicinity that is approximate to where the acidic phenolic
hydrogen of estradiol is. I suspect it is a potent estrogen agonist'
Clearly if this is the case we can only combat the estrogenic side effects
of oxymetholone with estrogen receptor antagonists such as Nolvadex or
Clomid, and not with an aromatase inhibitor. The strong anti-aromatase
compounds such as Cytadren and Arimidex would similarly prove to be totally
useless with this steroid, as aromatase is uninvolved.
Anadrol 50 is also a very potent androgen. This trait tends to
produce many pronounced, unwanted androgenic side effects. Oily skin,
acne and body/facial hair growth can be seen very quickly with this drug.
Many individuals respond with severe acne, often requiring medication
to keep it under control. Some of these individuals find that Accutaine
works well, which is a strong prescription drug that acts on the sebaceous
glands to reduce the release of oils. Those with a predisposition for
male pattern baldness may want to stay away from Anadrol 50 completely,
as this is certainly a possible side effect during therapy. And while
some very adventurous female athletes do experiment with this compound,
it is much too androgenic to recommend. Irreversible virilization symptoms
can be the result and may occur very quickly, possibly before you have
a chance to take action.
It is interesting to note that Anadrol 50 does exhibit some tendency
to convert to dihydrotestosterone, although this does not occur via the
5-alpha reductase enzyme (responsible for altering testosterone to form
DHT) as it is already a dihydrotestosterone based steroid. Aside from
the added c-17 alpha alkylation (discussed below), oxymetholone differs
from DHT only by the addition of a 2-hydroxymethylene group. This grouping
can be removed metabolically however, reducing oxymetholone to the potent
androgen l7alpha-methyl dihydrotestosterone (mesterolone; methyldihydrotestosterone)~.
There is little doubt that this biotransformation contributes at least
at some level to the androgenic nature of this steroid, especially when
we note that in its initial state Anadrol 50 has a notably low
binding affinity for the androgen receptor. So although we have the option
of using the reductase inhibitor finasteride (see: Proscar) to reduce
the androgenic nature of testosterone, it offers us no benefit with Anadrol
50 as this enzyme is not involved.
The principle drawback to Anadrol 50 is that it is a 17alpha alkylated
compound. Although this design gives it the ability to withstand oral
administration, it can be very stressful to the liver. Anadrol 50
is particularly dubious because we require such a high milligram amount
per dosage. The difference is great when comparing it to other oral steroids
like Dianabol or Winstrol, which have the same chemical alteration. Since
they have a slightly higher affinity for the androgen receptor, they are
effective in much smaller doses (seen in the 5mg and 2mg tablet strengths).
Anadrol 50 has a lower affinity, which may be why we have a 50mg
tablet dosage. For comparison, taking three tablets of Anadrol 50
(150mg) is roughly the equivalent of 30 Dianabol tablets or 75 Winstrol
tablets(!). When looking at the medical requirements, the recommended
dosage for all ages has been 1 - 5 mg/kg of body weight. This would give
a 2201b person a dosage as high as 10 Anadrol 50 tablets (500mg)
per day. There should be little wonder why when liver cancer has been
linked to steroid use, Anadrol 50 ~ is generally the culprit. Athletes
actually never need such a high dosage and will take in the range of only
1-3 tablets per day. Many happily find that one tablet is all they need
for exceptional results, and avoid higher amounts. Cautious users will
also limit the intake of this compound to no longer than 4-6 weeks and
have their liver enzymes checked regularly with a doctor. Kidney functions
may also need to be looked after during longer use, as water retention/high
blood pressure can take a toll on the body. Before starting a cycle, one
should know to give Anadrol 50 the respect it is due. It is a very
powerful drug, but not always a friendly one.
When discontinuing Anadrol 50 , the crash can be equally powerful.
To begin with, the level of water retention will quickly diminish, dropping
the user's body weight dramatically. This should be expected, and not
of much concern. What is of great concern is restoring endogenous testosterone
production. Anadrol 50 will quickly and effectively lower natural
levels during a cycle, so HCG
are a must when discontinuing a cycle.
The common practice of slowly tapering off your pill dosage is wholly
ineffective at raising testosterone levels. Without ancillary drugs, a
run away cortisol level will likely strip much of the muscle that was
gained during the cycle. If HCG and/or Clomid/Nolvadex are used properly,
the person should be able to maintain a considerable amount of new muscle
mass. Before going off, some alternately choose to first switch over to
a milder injectable like Deca-Durabolin. This is in an effort to harden
up the new mass, and can prove to be an effective practice. Although a
drop of weight due to water loss is likely when making the switch, the
end result should be the retention of more (quality) muscle mass with
a less pronounced crash. Remember ancillaries though, as testosterone
production will not be rebounding during Deca therapy.